【摘要】 目的探讨延长哌拉西林他唑巴坦给药时间法治疗铜绿假单胞菌感染的疗效。方法选择2007年～2010年11月病原学确诊为铜绿假单胞菌感染,且对哌拉西林他唑巴坦不耐药的住院患者167例,治疗前按随机数字法随机分为2组,延长时间组对哌拉西林他唑巴坦敏感患者采用哌拉西林他唑巴坦4.5g,静脉滴注,q6h,每次以输液泵控制输注时间为45min;对哌拉西林他唑巴坦中介的铜绿假单胞菌感染患者采用哌拉西林他唑巴坦4.5g,静脉滴注,q6h,每次以输液泵控制输注时间为45min联合妥布霉素1.7mg·kg-1,静脉滴注,qd。常规给药组对哌拉西林他唑巴坦敏感患者采用哌拉西林他唑巴坦4.5g,静脉滴注,q6h;对哌拉西林他唑巴坦中介的铜绿假单胞菌感染患者采用哌拉西林他唑巴坦4.5g,静脉滴注,q6h,联合妥布霉素1.7mg·kg-1,静脉滴注,qd。其他治疗方法相同。结果延长时间组疗效、总有效率、住院时间优于常规给药组,不良反应发生率无统计学差异。结论在相同剂量下,采用延长给药时间方法,可使哌拉西林他唑巴坦的fT﹥MIC达到或超过给药间期的40%～50%,从而达到良好的疗效。更多还原

【Abstract】 OBJECTIVE To explore the treatment efficacy of Pseudomonas aeruginosa infection by extend the administration time of piperacillin tazobactam. METHODS 167 hospitalized patients with Pseudomonas aeruginosa infection diagnosed by etiological diagnosis from Nov. 2007-Nov. 2010, and these patients showed drug resistance of piperacillin tazobactam. Before treatment, all the patients were randomly divided into two groups. Time extension group showed sensitive to piperacillin tazobactam and they were treated with 4.5 piperacillin tazobactamg, intravenous infusion for q6h. Each infusion pump was within 45min; Patients with Piperacillin tazobactam against Pseudomonas aeruginosa infection were treated by 4.5 g piperacillin tazobactam, intravenous infusion for q6h, and each infusion pump was within 45min. They were injected with 1.7mg / kg tobramycin, and intravenous drip for q6d. Conventional treatment group patients were sensitive to piperacillin tazobactam on 4.5 g piperacillin tazobactam and q6h intravenous infusion; Piperacillin tazobactam against Pseudomonas aeruginosa infection was treated by 4.5 g piperacillin tazobactam, q6h, intravenous drip and 1.7mg / kg tobramycin was used to them at the same time, and qd intravenous drip. The other treatments were the same. RESULTS The time extension could improve the efficiency than the conventional treatment group, and the incidence of adverse reactions did not show significant difference. CONCLUSION During the same dosage treatment, the extension of administration time can piperacillin tazobactam in the fT﹥ MIC meet or exceed the dosing interval of 40% -50%, and achieve good results.更多还原