【摘要】 目的探讨强迫症(OCD)共病抑郁的发生率、临床特征以及强迫症状和抑郁之间的关系。方法入组252名OCD患者,用耶鲁-布朗强迫量表(Y-BOCS)和强迫维度量表(DY-BOCS)评估强迫症的严重度和症状维度,用抑郁自评量表(SDS)和焦虑自评量表(SAS)评估抑郁和焦虑症状。结果 252名强迫症患者有79人共病抑郁(占31.3%)。共病者已婚少、发病年龄早、有高的教育水平。共病抑郁者强迫观念分、强迫行为分及其总分,抑郁分、焦虑分均显著高于非共病者,差异有统计学意义(P﹤0.01或P﹤0.05)。二分类Logistic回归分析显示,有关性(OR=2.116,95%CI1.550～2.887)、攻击(OR=1.377,95%CI1.088～1.743)、对称(OR=1.655,95%CI1.155～2.370)3类强迫症状维度是OCD共病抑郁的危险因素。结论 OCD共病抑郁的发生率31.3%,共病者有较多的心理病理症状;与性、攻击、对称相关的强迫症状是OCD共病抑郁的危险症状。更多还原

【Abstract】 OBJECTIVE To assessed prevalence and clinical characteristics of comorbidity of obsessive-compulsive disorder(OCD)and depression,and to analyze the relationship between depression and symptom dimensions of OCD.METHODS A total of 252 OCD patients were recruited in current study.Yale-Brown Obsessive-Compulsive Scale(Y-BOCS)and Dimensional Yale-Brown Obsessive-Compulsive Scale(DY-BOCS)were employed to assess the severity of OCD and symptom dimensions respectively.Self-rating Depression Scale(SDS)and Self-rating Anxiety Scale(SAS)were used to measure the severity of depressive and anxious symptoms.RESULTS The prevalence rate of comorbid OCD and depression was 31.3%.Compared with non-depression patients,the depression patients were less likely to be married,younger at onset and achieved a higher educational level.The scores of obsession,compulsion and total,depression and anxiety were significantly higher in comorbid depressed patients than that of non-depression patients(P﹤0.01 or P﹤0.05).By binary Logistic regression,obsessions and compulsions about sexual(OR=2.116,95%CI 1.550-2.887),aggressive(OR=1.377,95%CI 1.088-1.743)and symmetry(OR=1.655,95%CI 1.155-2.370)were associated with comorbid OCD and depression.CONCLUSION The prevalence rate of comorbid OCD and depression was 31.3%.Depression OCD patients present more severe general psychopathology.Obsessions and compulsions were related to sexual,aggressive and symmetry symptoms may be the risk factors for commorbid depression.更多还原