【摘要】 [目的]观察急性胰腺炎(AP)患者血清抵抗素水平的变化,并探讨其临床意义。[方法]选择AP患者46例,以正常健康人40例为正常对照组。所有AP患者均于起病后24h内入院,并根据Ransons’11项指标及CT评定进行轻重分型,其中轻型(MAP)25例,重型(SAP)21例。所有入选者分别于入院治疗d1、d3、d7检测血清高敏C-反应蛋白(hs-CRP)和抵抗素水平。[结果](1)在AP患者入院d1、d3、d7,SAP和MAP患者的血清抵抗素和hs-CRP水平均明显高于正常对照组(P﹤0.01);而SAP与MAP对比,SAP患者的血清抵抗素和hs-CRP水平显著高于MAP患者(P﹤0.05)。(2)所有AP患者的血清抵抗素与hs-CRP浓度有良好的正相关性(r=0.329,P﹤0.05)。[结论]抵抗素参与了AP的发病过程,可以作为AP早期诊断、严重程度评估的重要血清学指标。更多还原

【Abstract】 [Objective]To observe changes of serum resistin level in patients with acute pancreatitis(AP),and study its clinical significance.[Methods]46 patients with AP were chosen to AP group,and 40 healthy subjects were selected as control group.All AP patients were admitted within 24h after onset,and were divided into mild acute pancreatitis(MAP)with 25 cases and severe acute pancreatitis(SAP)with 21 cases according to Ransons’ 11 indicators and CT.Serum high-sensitivity C-reactive protein(hs-CRP)and resistin levels were tested at the time of 1,3 and 7 day after hospitalization in all subjects.[Results](1)The serum resistin and hs-CRP levels in the AP patients was significantly higher than that in the control group(P﹤0.01)at the time of 1,3 and 7 day after hospitalization.Compared to that in the MAP group,resistin and hs-CRP level in the SAP group was obviously increased(P﹤0.05).(2)Serum resistin and hs-CRP levels in the AP patients had a good positive correlation(r = 0.329,P﹤0.05).[Conclusion]Resistin may take part in the pathogenesis of AP,and it can be used as an important serum markers of early diagnosis and severity assessment in AP patient.更多还原