【摘要】 背景:关于不同运动强度对机体的影响早有研究,并且取得了不少有价值的成果。但是对于不同运动强度对线粒体Na+,K+-ATP酶、Ca2+-ATP酶活性以及线粒体肿胀程度影响的研究较少。目的:观察不同运动强度对大鼠骨骼肌线粒体Na+,K+-ATP酶和Ca2+-ATP酶以及线粒体肿胀的影响。方法:将24只SD大鼠随机分为正常对照组,中等强度运动组和高强度运动组。正常对照组大鼠正常笼内生活,不运动。另2组游泳训练方式,分别建立中强度和高强度运动模型,进行相应的运动锻炼,训练4周。结果与结论:中强度运动组线粒体Na+,K+-ATP酶、Ca2+-ATP酶活性与正常对照组相比均增高(P<0.05),线粒体肿胀程度降低(P<0.05);而高强度运动组线粒体Na+,K+-ATP酶、Ca2+-ATP酶活性与正常对照组相比均降低(P<0.05),线粒体肿胀程度增大(P<0.05)。实验结果表明中强度运动可以保护线粒体Na+,K+-ATP酶、Ca2+-ATP酶的活性,提高线粒体功能;而高强度运动则降低了线粒体的功能。更多还原

【Abstract】 BACKGROUND:There are many studies on the effects of different exercise intensities on the body,but studies about the effects of different exercise intensities on the activity of mitochondrial Na+,K+-adenosine triphosphatase(ATPase),Ca2+-ATPase and mitochondrial swelling are few.OBJECTIVE:To investigate the effects of different exercise intensities on the activity of mitochondrial Na+,K+-ATPase and Ca2+-ATPase,as well as mitochondrial swelling.METHODS:Twenty-four Sprague Dawley rats were randomly separated into three groups,namely,control,mid-intensity,high-intensity exercise groups.The control rats did not undergo swimming training,while the other two groups were given 4-week swimming exercises of different intensities.RESULTS AND CONCLUSION:Compared with the control group,the Na+,K+-ATPase and Ca2+-ATPase activities increased(P<0.05) and the extent of mitochondrial swelling decreased(P<0.05) in the mid-intensity exercise group,but opposite in the high-intensity exercise group.These findings indicate that mid-intensity exercise can protect the activity of mitochondrial Na+,K+-ATPase and Ca 2+-ATPase and increase the function of mitochondria,but high-intensity exercise can decrease the function of mitochondria.更多还原