【摘要】 背景:ε-己内酯与DL-丙交酯共聚后具有良好的生物相容性和可调控的降解速率,它的应用与其体内降解性能有着重要关系。目的:观察聚(己内酯-co-DL-丙交酯)在大耳白兔体内的降解性能。方法:将不同配比DL-丙交酯和ε-己内酯组成的聚(己内酯-co-DL-丙交酯)制备成不同尺寸的试样,植入到日本大耳白兔背部皮下,定期观察试样的形态、失重率、相对分子质量和热性能。结果与结论:随着ε-己内酯投料比的增加,聚(己内酯-co-DL-丙交酯)形状保持能力增强,降解速度减慢;相同共聚组成的试样,尺寸越大,降解速度越快。更多还原

【Abstract】 BACKGROUND:Copolymers of ε-caprolactone and DL-lactide (PCDLA) have good biocompatibility and adjustable degradation rate.And there is an important relationship between the application of PCDLA and its degradation property in vivo.OBJECTIVE:To investigate the degradation property of PCDLA in vivo of big ear rabbits.METHODS:The PCDLA with different copolymer compositions were made into samples with different sizes,and the samples were implanted in the back of Japanese big ear rabbits subcutaneously.The morphology,weight loss rate,number-average molecular weight and thermal properties of the samples were observed regularly.The degradation property of PCDLA in vivo was evaluated.RESULTS AND CONCLUSION:The results showed that the PCDLA shape retention was enhanced and degradation rate was slowed down with the feed ratio of ε-caprolactone increased.These suggest that for the same copolymer composition of samples,the larger size,and the faster degradation rate.更多还原