【摘要】 背景:相关研究表明壳聚糖能够提高机体免疫力,具有辐射保护作用。目的:研究在重离子放疗中纳米壳聚糖对肿瘤细胞的放射增敏作用和对骨细胞的防护作用。方法:MTT法检测纳米壳聚糖对人鼻咽癌KB细胞重离子辐射的增敏作用、对鼠成骨细胞MC3T3-E1细胞重离子辐射的防护作用。结果与结论:纳米壳聚糖对人鼻咽癌KB细胞具有放射增敏作用,随着纳米壳聚糖剂量的增加,重离子对肿瘤细胞的杀伤作用显著增强,同时也发现壳聚糖可增强鼠成骨细胞对重离子辐射损伤的耐受性。说明纳米壳聚糖具有对肿瘤细胞放射增敏和对正常组织细胞辐射防护的双重作用。更多还原

【Abstract】 BACKGROUND:Chitosan has been proved to enhance immunity and play a radiation protection role.OBJECTIVE:To investigate nano-chitosan protection effect on osteoblasts MC3T3-E1 cell line and sensitization effect for human nasopharyngeal carcinoma cell line KB radiated by ion-heavy.METHODS:Radiation protection and sensitization effect was detected by MTT assay.RESULTS AND CONCLUSION:Proliferation of KB cell line was inhibited by nano-chitosan,and the nano-chitosan showed a dose-dependent effect to the dosage of ion-heavy radiation.To osteoblasts MC3T3-E1 cell line,nano-chitosan showed a protection effect.The nano-chitosan plays the dual role of radiotherapy sensitization and radiation protection on different cells.更多还原