【摘要】 神经干细胞是指一类具有自我更新能力和多向分化潜能的细胞,能分化成为神经元、星形胶质细胞、少突胶质细胞等众多神经细胞。成年哺乳动物内源性神经再生能力有限,无法弥补因神经疾病而导致的神经细胞缺失,因而,人们开始寻求外源性神经干细胞移植治疗中枢神经系统疾病的可能,在动物模型上开展了大量研究,并建立了多种移植方法。该文就神经干细胞的特性、来源、移植方式、在中枢神经系统疾病中的实验研究进展等作一综述。更多还原

【Abstract】 Neural stem cells(NSCs) are the self-renewing,multi-potent cells that generate the main phenotypes of the nervous system,including neurons,astrocytes,oligodendrocytes and so on.The intrinsic neurogenesis of adult mammals is limited and can not compensate for the neuronal loss caused by nervous diseases.So,the researchers are exploring the novel treatments for central nervous diseases by exogenous neural stem cells transplantation.Up to now,many animal studies have been performed in this field,and several transplantation techniques are developed.The review focuses on the properties and original sources of NSCs,the means of engraftment,and the recent progress of research in NSCs transplantation.更多还原