【摘要】 目的了解深圳地区性病门诊患者感染泌尿生殖道沙眼衣原体(Chlamydia trachomatis,CT)、淋球菌(Neisseria gonorrhoeae,NG)和支原体的情况,以及支原体的耐药情况。方法对2010年深圳慢性病防治中心性病门诊的1 010例患者的泌尿生殖道标本,进行CT、NG核酸检测以及支原体培养、药敏试验。结果 1 010例患者中,CT阳性295例(29.2%),NG阳性103例(10.2%),解脲支原体(Ureaplasma urealyticum,UU)或/和人型支原体(Mycoplasma hominis,MH)阳性428例(42.4%)。其中CT和NG感染率男性高于女性,支原体感染情况则是女性高于男性。NG感染者中合并CT感染的比例(38.8%)高于CT感染者中合并NG的比例(13.6%);CT感染者中合并UU/MH感染的比例(47.1%)高于NG感染者中合并UU/MH感染的比例(30.1%)。对428例支原体药敏结果进行分析,UU耐药率最高的是环丙沙星(68.0%),MH及UU+MH混合感染耐药率最高的均是红霉素,分别为72.7%和90.4%。而UU、MH及UU+MH敏感率最高的均是交沙霉素,敏感率分别达98.3%、95.5%、91.3%,其次为强力霉素和美满霉素。结论深圳地区CT、NG和支原体的感染率均处在较高的水平,不同病原体混合感染的情况有所不同,感染存在性别差异。支原体感染以UU为主,交沙霉素、强力霉素和美满霉素可作为治疗支原体感染的首选药物。更多还原

【Abstract】 To explore the urogenital infection status of chlamydia trachomatis(CT),neisseria gonorrhoeae(NG),ureaplasma urealyticum(UU) and mycoplasma hominis(MH) in sexually transmitted disease(STD) clinic attendees in Shenzhen.Methods Urogenital specimens from 1 010 patients attending STD Clinic of Shenzhen Center for Chronic Disease Control were collected and detected for CT,NG and mycoplasma culture and drug-susceptibility.Results Among the 1 010 patients,the prevalence of infection with CT,NG and UU or/and MH were 29.2%,10.2% and 42.4% respectively.The positive rate of mycoplasma among females was higher than among males and the positive rates of CT,NG were on the contrary.Co-infection with CT among NG-positives(38.8%)was higher than the co-infection with NG among CT-positives(13.6%).Co-infection with UU/MH among CT-positives(47.1%)was higher than the co-infection with UU/MH among NG-positives(30.1%).Of the 428 cases of mycoplasma infection,the most resistant drug in UU,MH and the co-infection of UU and MH was ciprofloxacin(68.0%),erythromycin(72.7%) and erythromycin(90.4%) respectively.Both UU or/and MH were most sensitive to josamycin(UU 98.3%,MH 95.5%,both 91.3%),followed by doxycycline and minocycline.Conclusion The data above indicates that the infection rates of CT,NG and mycoplasma in Shenzhen keep a higher level.Mixed infection of different pathogens is diversified and there are gender differences in infection.The main urogenital mycoplasma infection is UU.Josamycin,doxycycline and minocycline may be used in genital tract infections of mycoplasma as the first line drugs.更多还原