【摘要】 目的比较度洛西汀及帕罗西汀治疗酒精依赖伴抑郁障碍的疗效及安全性。方法将符合入组标准的66例酒精依赖伴抑郁障碍患者随机分为度洛西汀组(实验组)及帕罗西汀组(对照组)。分别于基线时及第2、4、6周末,采用汉密尔顿抑郁量表(HAMD)评定疗效,用副反应量表(TESS)评定不良反应。结果共完成61例,实验组31例,对照组30例。(1)治疗6周末,两组疗效相当(t=1.626,P>0.05),且HAMD减分率差异无统计学意义(χ2=6.463,P>0.05);(2)第2、4周时,度洛西汀组和帕罗西汀组HAMD的减分率有统计学意义(t=2.060,2.027;均P<0.05),度洛西汀组高于帕罗西汀组;(3)度洛西汀组不良反应发生率显著低于帕罗西汀组,两组有统计学意义(χ2=4.322,P<0.05)。结论度洛西汀治疗酒精依赖伴抑郁障碍起效快,疗效与帕罗西汀相当,且不良反应少。更多还原

【Abstract】 Objective To compare the clinical efficacy and safety of the alcoholism superimposed depressive disorder treated with Paroxetine and Duloxetine.Methods 66 patients with alcoholism superimposed depressive disorder were divided into paroxetine group and Duloxetine group with 33 patients respectively.On the baseline and the end of 2 and 4 weeks,the Hamilton Depression Scale(HAMD) was used to evaluate the clinical efficacy and Treatment Emergent Symptom Scale(TESS) was used to test the adverse.Results 61patients finished the study,30 paroxetine group and 31Duloxetine group.At the end of 6 weeks,there was not significant difference in the reduction of the HAMD score among the two groups(χ2 =6.463,P>0.05) Significant difference was found in scores between the two groupsat the end of 2 and 4 weeks(t=2.060,2.027,P<0.05) The rate of score reduction in the duloxetine group was higher than the one of the paroxetine groups.There was significant difference in the rate of adverse between the two groups(χ2=4.322,P>0.05).The rate of adverse in paroxetine group was higher than the one of the duloxetine group.Conclusion The efficacy of duloxetine treating alcoholism superimposed depressive disorder,was equivalent to the one of paroxetine.It is with more quick effects and less adverse.更多还原