【摘要】 目的:探讨FOXP1和pVHL在肾透明细胞癌(CCRCC)中的表达水平及其与临床病理特征的关系。方法:采用免疫组化法检测48例CCRCC中FOXP1和pVHL两种蛋白的表达,并对其与临床分期、病理分级、淋巴结转移等作相关性分析。结果:48例CCRCC中FOXP1阳性表达率为83.3%(40/48),其中3例呈胞膜、胞浆同时表达,9例呈胞核、胞浆同时表达,余28例仅呈胞浆表达。高级别(G3)CCRCC中FOXP1的阳性表达率明显低于低级别(G1、G2)CCRCC(P<0.05)。FOXP1与临床分期、淋巴结有无转移无明显相关性(P>0.05)。pVHL阳性表达率为52.1%(25/48),均为胞浆、胞膜表达。pVHL表达与病理分级、临床分期及淋巴结有无转移均无明显相关性(P>0.05)。9例FOXP1胞核、胞浆同时阳性的CCRCC中8例pVHL阳性,余31例FOXP1胞浆或胞膜表达的CCRCC仅17例pVHL阳性,FOXP1胞核表达与pVHL表达两者具有正相关性关系(r=0.594,P<0.05)。结论:FOXP1胞作为一种潜在的肿瘤抑制基因,在CCRCC中存在高表达,并可能参与肿瘤的发生。FOXP1胞核表达与pVHL表达的相关性提示两者可能存在某种调节机制。更多还原

【Abstract】 Objective: To investigate the expressions of FOXP1 and pVHL in renal clear cell carcinoma(RCC) and their clinical significance.Methods: The expressions of FOXP1 and pVHL in RCC were evaluated immunohistochemically by the two-step detection system(EnVision),and the correlation among their expressions,clinical stage,pathological grade and lymph node metastasis were analyzed.Results: FOXP1 expressed in 83.3% of(40/48) the RCC cases,3 of 48 cases showed membrane and cytoplasm staining,while 9 cases were stained in nuclear and cytoplasm,28 cases were stained in cytoplasm,FOXP1 expression in high grade(G3) cases was significantly lower than those in low grade(G1 and G2)(P<0.05).There was no correla-tion between FOXP1,clinical stage,pathological grade and lymphonode metastasis(P >0.05).pVHL expressed in 52.1%(25/48) of the RCC cases,all of cases showed membrane and cytoplasm staining,pVHL expression did not significantly correlate with clinical stage,pathological grade and lymphonode metastasis(P >0.05).Eight of 9 cases with FOXP1 nuclear and cytoplasm staining pattern showed pVHL positive simultaneously,There was statistically positive correlation between FOXP1 and pVHL expression.(r=0.594,P <0.05).Conclusion: As a poten-tial tumor suppressor gene,FOXP1 is highly expressed in RCCs and may participate tumorogensis,It may presence a mechanism between FOXP1 protein and pVHL protein.更多还原