【摘要】 由1-芳基-3,5-二甲基吡唑-4-羧酸与适当的有机锡反应,合成表征了一系列的1-芳基-3,5-二甲基吡唑-4-羧酸有机锡酯(1～14),并通过单晶衍射确定了1-苯基-3,5-二甲基吡唑-4-羧酸三乙基锡酯(7)的结构。该化合物与一分子水共同结晶,通过分子间O-H…O及O-H…N氢键形成二维网状结构。杀菌活性筛选表明新合成的化合物对于番茄早疫菌、花生褐斑菌、小麦赤霉菌、苹果轮纹菌及灰霉菌全部具有良好的生长抑制作用。1-苯基-3,5-二甲基吡唑-4-羧酸三乙基锡酯及1-(2-吡啶基)-3,5-二甲基吡唑-4-羧酸三乙基锡酯在50μg.mL-1浓度下的体外实验中表现出很高的生长抑制率。对于高活性的三取代锡羧酸酯进行了EC50值的测定,结果表明1-(2-吡啶基)-3,5-二甲基吡唑-4-羧酸三乙基锡酯对苹果轮纹菌的EC50值为0.06μg.mL-1,对小麦赤霉菌的EC50值为0.14μg.mL-1。更多还原

【Abstract】 A series of organotin 1-phenyl-3,5-dimethylpyrazole-4-carboxylates and 1-(2-pyridyl)-3,5-dimethyl-pyrazole-4-carboxylates(1 ～14) have been obtained and characterized by IR,NMR(1H,13C and 119Sn) and elemental analysis.The structure of triethyltin 1-phenyl-3,5-dimethylpyrazole-4-carboxylate 7 has been further confirmed by X-ray diffraction crystallography.This complex crystallizes with a molecule of water and forms an infinite 2D network through intermolecular O-H…O and O-H…N hydrogen bonds.Fungicide screening indicates that all complexes display good growth inhibition against Alternaria solani,Cercospora arachidicola,Gibberella zeae,Physalospora piricola and Botrytis cinerea.Moreover,high growth inhibition percentage at 50 μg.mL-1 was observed in vitro in case of triorganotin 1-phenyl-3,5-dimethylpyrazole-4-carboxylates and 1-(2-pyridyl)-3,5-dimethylpyrazole-4-carboxylates.The corresponding EC50 of these highly active triorganotin carboxylates have been detected.The value of EC50 of triethyltin 1-(2-pyridyl)-3,5-dimethylpyrazole-4-carboxylate is only 0.06 μg.mL-1 against Physalospora piricola and 0.14 μg.mL-1 against Gibberella zeae,respectively.更多还原