【摘要】 通过检测体系中游离Ca2+离子浓度及草酸钙(CaOxa)的粒径随时间的变化,研究了CaOxa的结晶动力学及3种羧酸盐对CaOxa结晶动力学的影响,这些羧酸盐为:一元羧酸盐甘氨酸钠(NaGlu)、二元羧酸盐酒石酸钠(Na2Tart)和三元羧酸盐柠檬酸三钠(Na3Cit)。在生理盐水中CaOxa的结晶动力学方程为r=kc3.3±0.3,平均反应速率常数(k)为(3.1±1.8)×109;3种抑制剂对k的影响程度从大到小为:Na3Cit>Na2Tart>NaGlu,但其平均反应级数(α)相差不大,α=3.2±0.1。Na3Cit、Na2Tart可抑制CaOxa晶体的生长和聚集过程,是潜在的肾结石抑制剂。更多还原

【Abstract】 The kinetics of calcium oxalate(CaOxa) crystallization and the effect of three carboxylates were studied by determining the changes of free Ca2+ ions concentration and the size of CaOxa crystallites with the reaction time.These carboxylates were monocarboxylic acid salt(NaGlu),dicarboxylic acid salt(Na2Tart),and tricarboxylic acid salt(Na3Cit),respectively.The dynamics equations of calcium oxalate crystallization in normal saline was r=kc3.3±0.3,the average reaction rate constant(k) was(3.1±1.8)×109.The effect of three inhibitors on k values was in the order from large to small: Na3Cit>Na2Tart>NaGlu>blank.However,there is little difference for the average reaction order(α) value and α=3.2±0.1.Since Na3Cit and Na3Tart can inhibit the growth and aggregation of CaOxa crystals,they may be potential inhibitors for formation of kidney stones.更多还原