【摘要】 背景:Brg1是一种抑癌基因,参与染色质重塑过程,在细胞增殖、分化过程中起重要作用。研究发现Brg1参与了某些恶性肿瘤的发生。目的:检测Brg1在结肠癌中的表达,初步探讨Brg1与结肠癌的关系。方法:应用免疫组化法检测30例结肠癌、30例结肠腺瘤、20例癌旁组织中Brg1的表达情况。结果:Brg1在结肠癌组织中的表达强度显著高于结肠腺瘤和癌旁组织(P<0.05),结肠腺瘤与癌旁组织中的表达强度差异无统计学意义(P=0.05)。Brg1在结肠癌、结肠腺瘤、癌旁组织中的阳性表达率分别为86.7%、60.0%、25.0%,结肠癌和结肠腺瘤组织Brg1阳性表达率显著高于癌旁组织(P<0.05),结肠癌组织Brg1阳性表达率显著高于结肠腺瘤组织(P<0.05)。结论:Brg1可作为判断结肠肿瘤分化程度的生物学指标。更多还原

【Abstract】 Background:Brg1 is a tumor suppressor gene which is involved in chromatin remodeling process and plays an important role in proliferation and differentiation of cells.Several studies have suggested that Brg1 is involved in the development of some malignancies.Aims;To investigate the expression of Brg1 in colon cancer and the possible relationship between Brg1 and colon cancer.Methods;Expression of Brg1 in 30 cases of cancerous tissue,30 cases of adenomatous tissue and 20 cases of paracancerous tissue were determined by immunohistochemistry.Results;Expression of Brg1 in cancerous tissue was significant higher than that in adenomatous tissue and paracancerous tissue(P <0.05),and no statistically significant difference was found between adenomatous tissue and paracancerous tissue(P =0.05 ). Expression rates of Brg1 in cancerous,adenomatous and paracancerous tissue were 86.7%,60.0%and 25.0%, respectively.Expression rates of Brg1 in cancerous and adenomatous tissue were significantly higher than that in paracancerous tissue(P < 0.05),and expression rate of Brg1 in cancerous tissue was significantly higher than that in adenomatous tissue(P < 0.05).Conclusions;Brg1 can be used as an biomarker for the evaluation of colon tumor differentiation.更多还原