Ni2+ is the major ion release from nickel-based dental casting alloy and carcinogens.The major polyphenolic constituent present in green tea,(-)epigallocatechin-3-gallate(EGCG),shows chemoprevention on human cancer.The aim of this study was to determine the interaction between EGCG and Ni2+ and the biological effects on tongue squamous cell carcinoma.The interaction of EGCG and Ni2+ was analyzed by LC/MS.The cell viability was assessed by the MTT reduction assay.The results of LC/MS indicated that [EGCG-2Ni...