【摘要】 目的探讨艾司西酞普兰治疗广泛性焦虑的疗效及安全性。方法将64例广泛性焦虑患者随机分为研究组(艾司西酞普兰组)与对照组(文拉法辛组)各32例,分别予艾司西酞普兰与文拉法新治疗,疗程均为6周。分别采用汉密尔顿焦虑量表(HAMA)、临床疗效总评量表-病情严重度(CGI-SI)、艾森贝格抗抑郁剂副反应量表(SERS)于治疗前及治疗第1,46周末进行评定。结果艾司西酞普兰组在治疗后各个时点2,,的HAMA总分、精神性症状分、躯体性症状分、CGI-SI评分均明显下降,与治疗前比较差异有统计学意义(P<0.05或P<0.01)。文拉法新组在治疗后第1周末躯体性症状分与治疗前比较差异有统计学意义(P<0.05),HAMA总分、精神性症状分、CGI-SI评分从治疗后第2周起明显下降,与治疗前比较差异有统计学意义(P均<0.01)。艾司西酞普兰组在治疗后各个时点躯体性症状分均低于对照组,两组比较差异均有统计学意义(P<0.05或P<0.01)。艾司西酞普兰组总有效率为84.28%,显效率为66.67%;与文拉法新组总有效率78.13%、显效率为53.33%比较差异均无统计学意义(P>0.05)。艾司西酞普兰组在治疗第1,周末SERS2总分与文拉法新组比较差异均有统计学意义(P<0.01)。治疗后6周末两组的SERS总分比较差异无统计学意义(P>0.05)。结论艾司西酞普兰治疗广泛性焦虑有良好疗效,起较更快,不良反应轻微。更多还原

【Abstract】 Objective Explore the efficacy and safety of escitalopram treatment of generalized anxiety.Methods 64 patients with refractory depression were randomly divided into study group(escitalopram group)and the control group(venlafaxine group)32 cases eacht,respectively taking of escitalopram and venlafaxine in the treatment lasted six weeks.Clinical efficacies were assessed with the Hamilton anxiety scale(HAMA)and the clinical global impression severity of illness(CGI-SI)and rating scale for side effects(SERS) before treatment and after treatment of 1,2,4,6 week.Results HAMA total score of the escitalopram group the various time points after treatment,symptoms of spiritual points,points of somatic symptoms,and CGI-SI scores were significantly decreased compared with before treatment difference was statistically significant(P<0.05 or P<0.01).The venlafaxine group somatic symptoms points in 1 week after treatment compared with before treatment difference was statistically significant(P<0.05).Escitalopram group at various points in time after treatment of somatic symptoms scores were lower than the control group,escitalopram group,the total effective rate was 84.28%,markedly effective rate was 66.67%;with the venlafaxine group,the total efficiency of 78.13%,effective rate of 53.33%.There was no difference statistically significant(P>0.05).Escitalopram group of treatment 1,2 weekend SERS total score the venlafaxine group differences were statistically significant(P<0.01).SERS total score in both groups 6 weeks after treatment,no significant difference(P>0.05).Conclusion Escitalopram treatment of generalized anxiety,the efficacy of the efficacy of faster,and adverse reactions are mild.更多还原