【摘要】 目的:研究急性脑梗死患者平均血小板体积(MPV)、血小板计数(PLT)、血小板分布宽度(PDW)的特点及临床意义。方法:将2 109例急性脑梗死患者按合并症分为5组:单纯脑梗死组297例、合并高血压组635例、合并糖尿病组456例、合并房颤组209例和合并血脂异常组512例。按是否复发分为初发组1 458例,复发组651例。比较2 109例脑梗死患者与480例健康体检者(对照组)的MPV、PLT和PDW。结果:脑梗死组MPV高于对照组,差异有统计学意义(P<0.05),2组间PLT、PDW比较差异无统计学意义(P>0.05)。5个脑梗死亚组间MPV、PLT水平差异有统计学意义(P<0.05):单纯脑梗死组MPV较其他组减小,合并房颤组MPV较其他组均增大(P<0.05或P<0.01),合并房颤组PLT较其他组减少(P<0.05);合并高血压组、合并糖尿病组、合并血脂异常组的MPV、PLT、PDW差异无统计学意义(P>0.05)。复发组与初发组的MPV、PLT、PDW差异无统计学意义(P>0.05)。结论:检测MPV对急性脑梗死的预防有重要意义,尤其对有合并症的患者。更多还原

【Abstract】 Objective: To study characteristics and clinical significance of mean platelet volume(MPV),platelet count(PLT) and platelet distribution width(PDW) in patients with acute cerebral infarction.Methods: A total of 2 109 patients with cerebral infarction were divided into five groups,including pure cerebral infarction group(n=297),hypertension with ce rebral infarction group(n=635),diabetes with cerebral infarction group(n=456),atrial fibrillation with cerebral infarction group(n=209) and dyslipidemia with cerebral infarction group(n=512).Patients were divided into the first time cerebral in farction group(1 458 patients) and the recurrent infarction group(651 patients).The values of MPV,PLT and PDW were com pared between patients with cerebral infarction and healthy control subjects(n=480).Results: There was a significant higher MPV in acute cerebral infarction group than that in control group(P< 0.05),while no significant differences in PLT and PDW between two groups(P > 0.05).There were significant differences in MPV and PLT between five cerebral infarction groups(P < 0.05).The value of PDW was significantly lower in pure cerebral infarction group than that of other four groups(P > 0.05),while MPV was significantly higher in atrial fibrillation with cerebral infarction group than that of other groups(P < 0.05 or P < 0.01).The value of PLT was significantly lower in atrial fibrillation with cerebral infarction group than that of oth er groups(P < 0.05).There were no significant differences in MPV,PLT and PDW between hypertension with cerebral infarc tion group,diabetes with cerebral infarction group and dyslipidemia with cerebral infarction group(P > 0.05).Also,there were no significant differences in MPV,PLT and PDW between recurrence group and the first time cerebral infarction group(P > 0.05).Conclusion: It is important to detect MPV for the prevention of acute cerebral infarction,especially for patients with complications(hypertension,diabetes,atrial fibrillation and dyslipidemia).更多还原