【摘要】 目的明确上海市陆家嘴地区公司职员非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)的发病率及相关危险因素。方法选取从2008年1月到2011年8月来同济大学附属东方医院体检的上海市陆家嘴地区公司在职职员,进行血液及肝脏超声检查。结果共3 532人完成调查,其中男性1 709人,平均年龄(41.99±9.04)岁,共检出NAFLD患者1 265例,患病率为35.8%,其中男性患病率为53.5%,女性为19.1%,男女性患病率均在41～50岁年龄组达到高峰(分别为61.3%和27.4%),在各个年龄组中男性患病率均高于女性(P<0.01)。Logistic回归分析发现年龄、体质量、血尿酸、血HDL-C及ALT与NAFLD独立相关。结论陆家嘴地区公司在职职员中NAFLD发病率高,与年龄、体质量、血尿酸、HDL-C及ALT水平相关。更多还原

【Abstract】 Objective To determine the prevalence and risk factors of non-alcoholic fatty liver disease(NAFLD) among office workers of Shanghai Lujiazui District.Methods Total 3 532 office workers with a mean age of 41.9 y,including 1709 men and 1823 women from Lujiazui District underwent health check-up in our hospital from August 2008 to August 2011.The results of physical examination,blood tests and sonography examination were analyzed.Results NAFLD was found in 1265(35.8%) subjects,with a prevalence rate of 53.5% in males and 19.1% in females.The prevalence of NAFLD in 41-50 age group was highest in both sex(61.3% and 27.4% for male and female respectively).Multivariate logistic regression analysis showed that age,body weight,blood uric acid,HDL-C and ALT levels were closely related to NAFLD.Conclusion NAFLD is a common finding in office workers of Shanghai Lujiazui District;age,weight,uric acid,HDL-C and ALT are risk factors for NAFLD.更多还原