【摘要】 目的:观察结缔组织生长因子肽(P1c)对大鼠动静脉旁路血栓形成的影响。方法:观察不同剂量(2、4、8 mg.kg-1)的P1c静脉给药对动静脉旁路血栓模型大鼠血栓形成的影响。结果:P1c高、中剂量组和阳性药阿司匹林组血栓湿重较生理盐水组显著下降(P<0.05),剂量与血栓形成抑制率呈明显正相关(r=0.997,P<0.05)。结论:P1c具有良好的抗血栓作用。更多还原

【Abstract】 Objective: To observe the effects of connective tissue growth factor peptide(P1c) on the thrombus formation by venoarterial bypass in rats.Methods: The thrombosis model was established by venoarterial bypass.P1c was injected via the femoral vein of rats at the dose of 2,4,and 8 mg·kg-1,respectively.Results: The groups of middle and high dose of P1c,as well as aspirin groups,could significantly inhibit the thrombosis formation compared with the blank group(P<0.05).The inhibited rate of thrombosis formation was a linear positive correlation with the dose of P1c.Conclusion: P1c has the characteristics of anti-thrombosis formation.更多还原