【摘要】 目的探讨超长方案与微刺激方案在卵巢低反应患者的应用价值,为卵巢低反应患者寻求最经济合理的刺激方案。方法选取101周期超长方案或微刺激方案行体外受精/卵胞浆内单精子注射(IVF/ICSI)助孕的卵巢低反应患者,其中56周期采用超长方案,为A组;45周期采用微刺激方案,为B组。比较两组的促性腺激素释放激素(gonadotropin,Gn)用量、使用Gn的时间、获卵数、可移植胚胎数、周期取消率和临床妊娠率。结果两组相比Gn用量、使用Gn的时间,A组均高于B组,差异有统计学意义(P<0.05)。周期取消率、获卵数、可移植胚胎数、临床妊娠率两组数值比较无统计学差异。结论在卵巢低反应患者采用超长方案增加Gn用量、延长使用Gn的时间,增加患者的经济负担,而周期取消率与采用微刺激方案无明显降低,获卵数、可移植胚胎数、临床妊娠率无增加。故对于卵巢低反应患者采用微刺激方案较经济,且治疗周期短,有利于减轻患者的经济负担且节省治疗时间。更多还原

【Abstract】 Objective:To investigate the difference of clinical outcomes using super-long protocol or minimal ovarian stimulation in poor ovarian responder. Methods:A total of 101 poor ovarian responders in IVF/ICSI with super-long protocol or minimal ovarian stimulation were divided into two groups.Fifty six cycles in group A were administrated superlong protocol and 45 cycles in group B were used minimal ovarian stimulation protocol.The dose of gonadotropin(Gn),the days of Gn administration,the number of oocytes retrieved,the number of fertilized embryos,the cancellation rate and pregnancy rate were compared between the two groups. Results:The dose of Gn and the days of Gn administration in group A were significantly higher than those in group B(P<0.05).There were no significant differences in the number of oocytes,the number of fertilized embryos,the cancellation rate and pregnancy rate between two groups. Conclusions:The dose of Gn and the days of Gn administration increased significantly,however the number of oocytes,the number of fertilized embryos,the cancellation rate and pregnancy rate were not significantly different,when the super-long protocol was used instead of minimal ovarian stimulation for the poor ovarian responders.Therefore,minimal ovarian stimulation with advantages of shorter treatment cycle and lower expenses seems more efficient and economic.更多还原