【摘要】 1例55岁女性患者,10年余前经手术病理确诊为原发性甲状腺乳头状癌。术后8年出现颈部淋巴结转移并再次接受手术治疗。此后的3年时间里,患者多次出现复发并手术治疗,由甲状腺乳头状癌转变为乳头状癌伴鳞化,进而转变为甲状腺鳞状细胞癌,最终因疾病迅速恶化死亡。甲状腺鳞癌可直接来源于腺癌或乳头状癌鳞状化生,一旦发生转变,则意味着疾病将可能加速进展,呈现高度恶化趋势,预后极差,需引起高度重视。更多还原

【Abstract】 A 55-year-old female patient underwent surgery for her thyroid lumps 10 years ago and pathological examination confirmed the diagnosis of primary papillary carcinoma of the thyroid.The metastasis of neck lymph nodes was conformed 8 years after operation,and the patient received metastatic lymph nodes resection.During the 3-year follow-up the patient had recurrent tumor.The pathological results showed that the lesion changed from papillary carcinoma to papillary carcinoma accompanied with squamous differentiation and transformed to squamous cell carcinoma of the thyroid at last.Finally the patient died from deterioration of the disease rapidly.From the literature review,it has been shown that the squamous cell carcinoma of the thyroid might originate from adenocarcinoma or squamous metaplasia of papillary carcinoma.Once the transformation occurs,the progress of the disease may be accelerated.This transformation is rare and usually confers a poor prognosis.更多还原