【摘要】 目的检测Jagged-1在子宫颈癌组织中的表达情况,探讨其在子宫颈癌发生、发展中的作用机制。方法采用免疫组织化学EnVision法检测60例子宫颈癌和21例正常子宫颈组织中Jagged-1的表达情况。结果Jagged-1在子宫颈鳞癌、腺癌组织中及正常组织中的阳性率分别为72.5%、80.0%和23.8%,在子宫颈鳞癌、腺癌组织中的表达水平高于正常子宫颈组织,差异有统计学意义(P<0.05)。结论 Jagged-1在子宫颈癌中的表达升高,提示其可能参与了子宫颈癌的发生、发展过程。更多还原

【Abstract】 Objective To explore the expression of Jagged-1 protein and to investgate it′s mechanism in the occurrence and development of cervical cancer. Methods EnVision immunohistochemical technique was used to detect the expression of Jagged-1 protein in 60 cases of cervical cancer and 21 cases of normal cervical tissue. Results The expression rates of Jagged-1 in the cervical squamous cell carcinoma,adenocarcinoma and normal cervical tissue were 72.5%,80.0%,23.8%,respectively,which were higher in cervical squamous cell carcinoma and adenocarcinoma than those in normal cervical tissue(P<0.05). Conclusion The increased expression of Jagged-1 protein may participate in the occurrence and development of cervical cancer.更多还原