【摘要】 目的:探讨肾病综合征患者并发急性胰腺炎的危险因素及临床特征。方法:对768例肾病综合征患者的完整临床资料进行回顾性分析,比较肾病综合征患者并发急性胰腺炎者(有急性胰腺炎组)与不并发组者(无急性胰腺炎组)临床特征、实验室检查等方面的差异;利用单因素及多因素分析探讨肾病综合征患者并发急性胰腺炎的危险因素。结果:肾病综合征患者并发急性胰腺炎的发生率为4.1%,男女性别差异无统计学意义(P>0.05),单因素分析提示胆道疾病(P<0.05;χ2=33.17)、不合理饮食(P<0.05;χ2=30.34)、肥胖(P<0.05;χ2=5.83)是并发急性胰腺炎的危险因素。多因素Logistic回归分析提示胆道疾病(P=0.000;OR8.164;95%CI2.814～23.686)、不合理饮食(P=0.001;OR5.811;95%CI2.003～16.856)是并发急性胰腺炎的独立危险因素。结论:合理的饮食习惯、控制体质量及胆道疾病的发作,可预防或减少肾病综合征患者急性胰腺炎的发生。更多还原

【Abstract】 Objective To identify the risk factors for acute pancreatitis in patients with nephrotic syndrome.Methods Clinical data of 768 patient with nephrotic syndrome were retrospectively analyzed.Clinical and laboratory findings were compared between patients with nephrotic syndrome combined with or without acute pancreatitis.Results The incidence of acute pancreatitis in patients with nephrotic syndrome was 4.1%.Single-variable analysis showed that biliary tract diseases(χ2 = 33.17,P < 0.05),obesity(χ2 = 5.83,P < 0.05) and unreasonable diet(χ2 = 30.34,P < 0.05) were the main risk factors for acute pancreatitis in patients with nephrotic syndrome.Multi-variable Logistic analysis showed that the independent factors for acute pancreatitis in patients with nephrotic syndrome were the biliary tract disease(P = 0.000,OR = 8.164,95%CI 2.814 ～ 23.686) and unreasonable diet(P = 0.001,OR = 5.811,95% CI 2.003 ～ 16.856).Conclusion A reasonable diet,controlling body mass and the occurrence of biliary diseases are important in decreasing the incidence of acute pancreatitis in patients with nephrotic syndrome.更多还原