【摘要】 目的观察噻托溴铵联合沙美特罗替卡松对慢性阻塞性肺疾病(COPD)稳定期的治疗效果。方法采用随机、双盲的方法将62例COPD患者分为观察组和对照组,观察组给予噻托溴铵和沙美特罗替卡松治疗,对照组给予沙美特罗替卡松治疗,分别对两组患者治疗前后呼吸困难评分和肺功能检测进行比较。结果治疗两个月后,与对照组比较观察组肺功能FEV1、FVC、FEV1/FVC%,呼吸困难评分改善差异有统计学意义(P<0.05)。结论噻托溴铵与沙美特罗替卡松联合吸入治疗COPD,疗效优于沙美特罗替卡松单药治疗。更多还原

【Abstract】 Objective To evaluate the effects of tiotropium bromide combined salmeterol/fluticasone propionate(SFC)for the treatment in patients with stable chronic obstructive pulmonary disease(COPD).Methods A randomized,double-blind clinical trial was conducted in 62 patients with stable COPD.The observation group was given tiotropium bromide combined with SFC,the control group was given SFC,the St George′s respiratory questionnaire(SGRQ)and pulmonary function was conducted at baseline,2 monthes after treatment.Results FEV1,FEV1/FVC% and SGRQ score in combined observation group were significantly superior to those of control group at 2 monthes after treatment(all P<0.05).Conclusion Tiotropium bromide combined SFC could further advance efficacy than SFC for the treatment in patients with stable COPD.更多还原