【摘要】 目的评价国产瑞舒伐他汀(舒夫坦)治疗低体质量女性血脂异常患者的疗效和安全性。方法 40例低体质量(BMI<19kg/m2)女性高胆固醇血症患者口服国产瑞舒伐他汀5mg/d 3个月,治疗结束后比较治疗前后患者总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)达标率及肝肾功能变化。结果治疗后TC、LDL-C较治疗前降低,差异有统计学意义(P<0.05)。TC、LDL-C达标率分别为44.6%和56.3%。三酰甘油(TG)和高密度脂蛋白胆固醇(HDL-C)与治疗前比较,差异无统计学意义(P>0.05)。治疗过程中未出现严重不良事件。结论国产瑞舒伐他汀5mg对低体质量女性血脂异常患者降低LDL-C的疗效好,安全性佳。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of domestic-made rosuvastatin in low body weight female patients with dyslipidemia.Methods 40 low body weight female patients with dyslipidemia toke rosuvastatin 5mg orally once daily for 3 months.The efficacy and safety of this treatment were evaluated after 3 months of treatment by evaluating the changes and compliance rate of TC,LDL-C.Results Comparing with the baseline,the TC and LDL-C decreased after 3 months treatment,which received a significant difference.The compliance rate of TC,LDL-C were 44.6 % and 56.3 % respectively.There were no significant differences when comparing the concentration of TG and HDL-C before and after rosuvastatin treatment.No serious adverse events related to the medication were observed.Conclusion Rosuvastatin may improve the lipid profile of dyslipidemia female patients with low body.更多还原