【摘要】 目的探讨血清基质金属蛋白酶-9(MMP-9)和高敏C反应蛋白(hs-CRP)在出血性脑梗死(HI)患者中的变化及临床意义。方法 52例患者检查明确诊断的HI住院患者,按临床神经功能缺损程度分级,在入院后第1,7,14天分别测定血清MMP-9和hs-CRP含量。结果 1 d、7 d、14 d血清MMP-9和hs-CRP的含量与对照组相比均明显增高,两者差异有统计学意义(P<0.01)。与1 d相比,轻度神经功能缺损患者血清MMP-9和hs-CRP含量均在7 d时显著增高(P<0.05或P<0.01),14 d时出现下降趋势;而中、重度神经功能缺损患者血清MMP-9和hs-CRP含量均在7 d时非常显著增高(P<0.01),14 d时则出现显著的下降(P<0.05或P<0.01)。血清中MMP-9与hs-CRP含量呈显著正相关。结论 MMP-9和hs-CRP可作为HI的早期诊断和判断病情及预后的指标之一。更多还原

【Abstract】 Objective To investigate the dynamic change and clinical significance of serum matrix metalloproteinase-9(MMP-9) and high sensitivity C reactive protein(hs-CRP) in the patients with hemorrhagic cerebral infarction.Methods Fifty two inpatients with hemorrhagic cerebral infarction were classified according to the clinical degree of neural function defect.The levels of serum MMP-9 and hs-CRP on d1,d7 and d14 after admission were detected respectively.Results The levels of serum MMP-9 and hs-CRP on d1,d7,d14 in the treatment group were significantly increased than that in the control group,the difference was statistically significant between the two groups(P<0.01).The levels of serum MMP-9 and hs-CRP on d7 were significantly higher than that on d7 in patients with mild neural function defect(P<0.05 or P<0.01);on d14,the levels showed a downward trend;but levels of serum MMP-9 and hs-CRP levels on d7 were significantly increased in patients with moderate and severe neural function defect(P<0.01),the levels on d14 showed a significant decline(P<0.05 or P<0.01).A positive correlation was found between Serum MMP-9 and hs-CRP levels.Conclusion MMP-9 and hs-CRP can be used as one of the indicators for the early diagnosis and judgment of condition and prognosis.更多还原