【摘要】 目的探讨影响早期胃印戒细胞癌淋巴结转移的潜在危险因素。方法对82例经手术治疗的早期胃印戒细胞癌患者的临床病理特征与淋巴结转移的相关性进行回顾性分析。结果早期胃印戒细胞癌淋巴结转移率为7.32%,早期胃印戒细胞癌淋巴结转移与患者溃疡情况(P=0.031)、浸润深度(P=0.023)、肿瘤大小(P=0.035)及脉管癌栓(P<0.001)有关,合并有溃疡(P=0.042)、浸润至黏膜下层(P=0.035)、肿瘤直径≥20 mm(P=0.032)及有脉管癌栓(P=0.002)是早期胃印戒细胞癌淋巴结转移的独立性危险因素。结论本组资料显示合并有溃疡、浸润至黏膜下、肿瘤直径≥20 mm及有脉管癌栓的早期胃印戒细胞癌患者有较高的淋巴结转移风险,应作为早期胃印戒细胞癌临床内镜治疗的重要考虑因素。更多还原

【Abstract】 Objective To explore the correlated pathological factors influencing the lymph node metastasis of early gastric cancer(EGC) with signet-ring cell histologic.Methods The clinicopathological data and lymph node metastasis in 82 patients with early gastric cancer of signet-ring cell histologic were retrospectively reviewed.Results Lymph node metastasis was detected in 6(7.32%) of the 82 patients.Univariate analysis revealed correlations between lymph node metastasis and various factors ranging from presence of an ulcer(P=0.031),depth of invasion(P=0.023),tumor size(P=0.035) to lymphatic involvement(P<0.001).However,in multivariate analysis,presence of an ulcer(P=0.042),invasion to the submucosal(P=0.035),tumor diameter≥20 mm(P=0.032),and lymphatic involvement(P<0.001) were found to be independent risk factors.Conclusion Clinicopathological characteristics such as presence of an ulcer,invasion to the submucosal,tumor diameter≥20 mm,and lymphatic involvement had a significant effect on lymph node metastasis.Therefore,the decision to use endoscopic treatment should be made more carefully,especially when there was an ulcer,tumor invasion to the submucosal,tumor diameter≥20 mm,and lymphatic involvement.更多还原