【摘要】 目的了解老年高血压患者肾动脉阻力指数(RI)与血压水平的关系,分析肾动脉RI与肾功能指标的相关性。方法选择老年原发性高血压患者134例,其中Ⅲ级67例,Ⅱ级35例,Ⅰ级32例,对照组29例,用彩色多普勒超声分别测量双侧主肾动脉的RI,同时检测血尿素氮(BUN)、肌酐(Cr)、肌酐清除率(CCr)、尿β2微球蛋白(β2-MG)、血同型半胱氨酸(Hcy)水平,比较各组之间RI及肾功能指标的差异;分析RI与肾功能指标的相关性。结果Ⅱ、Ⅲ级高血压患者肾动脉RI明显高于对照组(P<0.01)。Ⅲ级高血压患者血BUN、Cr、CCr、尿β2-MG、血Hcy显著高于对照组(P<0.05),Ⅱ级高血压患者尿β2-MG、血Hcy高于对照组(P<0.05)。相关分析显示肾动脉RI与BUN、Cr、Hcy、尿β2-MG呈正相关,与CCr呈负相关。结论老年高血压患者的RI与血压水平相关,联合尿β2-MG、血Hcy水平等肾功能指标的检测可反映早期肾功能受损情况。更多还原

【Abstract】 Objective To investigate the renal arterial resistive index (RI) in the aged hypertensive patients,and to analyze the correlation between renal arterial RI and blood pressure and kidney function. Methods 134 cases of aged primary hypertensive patients were selected,including 67 cases of hypertension Ⅲ,35 cases of hypertension Ⅱ and 32 cases of hypertension Ⅰ,and 29 subjects also were chosen as control group. Renal arterial RI was detected in all cases by color Doppler flow imaging. Blood urea nitrogen (BUN),serum creatinine (Cr),creatinine clearance rate (CCr),serum homocysieine (Hcy),urine β2 microglobulin(β2-MG)were measured in all cases. Results Renal arterial RI in patients with hypertension Ⅲ, Ⅱ was increased more significantly than that in control group (P<0.01). There was significant difference in kidney function in hypertension Ⅲ group compared with control group(P<0.05), but only urine β2-MG, Hcy in hypertension Ⅱ group were increased more significantly than those in control group (P<0.05). Renal arterial RI was positively correlated with BUN,Cr,Hcy,urine β2-MG,and negatively correlated with CCr. Conclusions Renal arterial RI is related to the blood pressure level in aged hypertensive patients, the combining measurement of urine β2-MG and serum homocysieine can reflect the damage of kidney function in the early stage.更多还原