【摘要】 目的 探讨磁共振T₁ map在膝关节软骨退变中的临床应用价值。方法 41例受检者共41例膝关节分为正常组（n=11）、轻度骨性关节炎（OA）组（n=20）和重度(OA组（n=10）,经肘静脉注射对比剂Gd-DTPA^2-90～120 min后行3.0T磁共振扫描,采用双反转角T₁map技术及后处理软件得到T₁图,分别测量股骨内、外侧髁,胫骨内、外侧髁等4处软骨T₁值并对各组间差异进行统计学分析。正常组、轻度OA患者、重度OA患者组间T₁值的比较采用q检验。结果 正常组、轻度OA组及重度OA组平均关节软骨T₁值分别为518.9～540.2ms、465.0～482.7ms、65.9～370.2 ms。正常组与OA组T₁值之间均存在显著性差异（P<0.001）,轻度OA组与重度OA组T₁值之间也存在显著性差异（P<0.001）。结论MR T₁ map可用于评价关节软骨生化成分的改变,并在早期关节软骨退变的诊断中具有较好的临床应用价值。更多还原

【Abstract】 Objective To evaluate the clinical application of MRI T₁ map in knee osteoarthritis（OA）.Methods 41 patients were divided into 3 groups:normal group（n=11）,mild OA group（n=20） and severe OA group（n=10）.They were all underwent3.0T MRI examination.90-120 min after Gd-DTPA^2- intravenous injected,T₁W images were obtained by using dual-angle T₁map technique and postprocessing software.The T₁ values of cartilage were measured at condylus medialis femoris,condylus lateralis femoris,condylus medialis tibial plateau and condylus lateralis tibial plateau.Statistical significance was inferred at P<0.05.Results The T₁ values of arthrodial cartilage in normal group,mild OA group and severity OA group were 518.9-540.2 ms,465.0-482.7 ms and 365.9-370.2 ms,respectively.There were significant differences among the three groups（P<0.001）.Conclusion MR T₁ map can be used in evaluating the articular cartilage changes and the biological composition.It plays an important role in the early diagnosis of cartilage degeneration.更多还原