【摘要】 目的 探讨MRI联合HLA-B27抗原检测骶髂关节强直性脊柱炎(AS)早期诊断的临床价值。方法 回顾性分析经临床确诊的35例早期AS患者,均行骶髂关节X线、MRI检查及HLA-B27抗原检测,并分别比较骶髂关节MRI、HLA-B27、骶髂关节MRI联合HLA-B27的阳性率。结果 35例早期强直性脊柱炎患者中,通过MRI检查诊断早期强直性脊柱炎的阳性率为74.3%(26/35例),HLA-B27阳性率为88.6%(31/35例),骶髂关节MRI联合HLA-JB27的阳性率为97.1%(34/35例),其中MRI联合HLAB27的阳性检出率高于MRI有统计学意义(P=0.013),MRI与HLA-B27、MRI联合HLA-B27与HLA-B27的阳性检出率比较无统计学意义(P>0.05)。结论 骶髂关节MRI联合HLA-B27检查能提高早期强直性脊柱炎的阳性检出率,有利于临床早期诊断、早期治疗。更多还原

【Abstract】 Objective To explore the clinical value of combination of Magnetic Resonance Imaging(MRI) and HLA-B27 in early diagnosis of ankylosing spondylitis(AS).Methods 35 patients with early AS proven by clinical examination were included in this study.All patients underwent X-ray,MRI and HLA-B27 examination before treatment.The positive rates in detecting AS were compared between MRI and combination MR imaging and HLA-B27.Results Among the 35 patients of early AS,only 26(74.3%)were diagnosed to be early AS by MRI,the positive rate of HAL-B27 was 88.6%,the positive rate of MRI combined with HLA-B27was 97.1%.The positive rate of MRI combined with HLA-B27 was significantly higher than that of MRI(P=0.013).While thepositive rates were not statistically significant between MRI and HLA-B27,and between MRI combined with HLA-B27and HLA-B27 alone(P>0.05).Conclusion Combination of MRI examination and HLA-B27 can improve the detecting rate early of AS.更多还原