【摘要】 目的 探讨脑桥随年龄变化规律及脑桥测量在橄榄脑桥小脑萎缩（OPCA）诊断中的价值。方法 253例正常人（21～80岁）按每10岁为1个年龄组共分6组,13例OPCA患者为病人组。在MRI正中矢状位T₁WI图像上,分别测量脑桥上下径（A线）、脑桥腹侧凸度（B线）、脑桥中部前后径（C线）、中脑前后径（D线）,将测得结果进行OPC A组和正常各年龄组间的比较。结果A-D线均随年龄增大有逐渐下降趋势,各径线正常各年龄组与OPCA组的差别均有显著统计学意义（P<0.05）。脑桥腹侧凸度（B线）正常人女性均>7.0 mm,男性均>8.0 mm,而OPCA患者均低于上述两值;而A、C、D线OPCA组和正常对照组间测量值有一定的重叠。结论 脑桥体积在20～40岁时达到顶峰,之后随年龄增长脑桥体积逐渐变小。脑桥腹侧凸度女性<7.0 mm,男性<8.0mm时诊断OPCA意义较大。更多还原

【Abstract】 Objective To study the change rules with aging of the pons and the values of the measurements of diameters of the pons in diagnosing olivopontocerebellar atrophy（OPCA）.Methods 253 healthy human（21-80 years old） to be divided into 6groups according to their ages（each group in 10 cases）and 13 cases of OPCA were involved in this study.The top to bottom（ A）,ventro-convexity（B）,anteroposterior（C） and midbrain anteroposterior diameters（D） of the pons were measured on midsagittal T₁WI MR images at PACS.The data were analyzed between healthy and OPCA cases.Results The values of A-D were gradually decline with aging.There were significant differences between healthy human and OPCA in A,B,C and D（P<0.05）.For OPCA patients,the ventro-convexity of pons were all less than 7.0 mm in female and less than 8.0 mm in male patients.But the minimum and maximum value of A,C,D had some overaps in OPCA patients and control human.Conclusion The volume of the pons reachs a peak at third and fourth decade,after that,the pons gradually atrophy with aging.It is greatly helpful for diagnosing OPCA that ventro-convexity of pons is below 7.0 mm in female or is below 8.0 mm in male patients.更多还原