【摘要】 目的比较长爪沙鼠高脂血症模型的4种造模方法。方法选取用于复制大鼠高脂血症动物模型的4种配方饲料,饲喂长爪沙鼠60 d,分别在0 d、30 d、60 d空腹12 h后眼眶取血,测定血清中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的含量,观察肝组织的形态学变化。结果4种高脂配方饲料在30 d、60 d均使长爪沙鼠血清的TC、HDL-C、LDL-C的值明显高于对照组,以TC升高最为明显,并且LDL-C的增加幅度明显大于HDL-C的增加,并出现不同程度的脂肪肝。结论 4种高脂配方饲料均可复制长爪沙鼠高脂血症模型。更多还原

【Abstract】 Objective To Compare four methods of developing hyperlipidemia in Mongolian gerbils.Method The gerbils in the experimental groups were fed respectively with four high-fat fodders with varying amounts of cholesterol,lard and cholate.The gerbils in the control group were fed with normal fodder.Serum levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) in the gerbils in all the groups were measured at the 0th,30th,60th day.Animals were sacrificed and the morphological changes of the liver were examined by histopathology.Result Serum levels of TC,LDL-C and HDL-C in gerbils of the experimental group were significantly higher than those in gerbils of the control group during the 30th,60th days,with a remarkable increase in serum TC level in particular,and increase of serum LDL-C were obviously bigger than the increase of serum HDL-C.There have been varying degrees of fatty liver in the experimental groups.Conclusion Four high-fat fodders can all cause hyperlipidemia in the gerbils.更多还原