【摘要】 目的研究DOG-1在胃肠道间质瘤(GIST)中的表达及其临床意义。方法应用免疫组织化学方法检测61例GIST中DOG-1的表达,并与CD117标记进行比较观察,分析DOG-1与GIST各临床病理特征的关系。结果CD117和DOG-1在极低度及低度危险性GIST组织中表达率分别为95.2%(20/21)和90.5%(19/21);在中度及高度危险性GIST中CD117和DOG-1阳性表达率分别为100.0%(40/40)和97.5%(39/40)。CD117表达与DOG-1无关;DOG-1表达与GIST发生部位、肿瘤大小、分级和年龄无关;DOG-1阴性与GIST复发及转移显著相关(P<0.01)。结论DOG-1可作为GIST诊断和预后判断的潜在参考指标。更多还原

【Abstract】 Objective To investigate the expression of DOG-1 in gastrointestinal stromal tumors(GIST) and its diagnostic significance.Methods Immunohistochemistry staining was performed on clinical specimens from 61 patients with GIST.Cross link between CD117 and DOG-1 expressions was examined to explore the value of DOG-1 on GIST diagnosis and prognosis.Results In very low and low risk groups of GIST,95.2%(20/21)and 90.5%(19/21)specimens could detect positive expression of CD117 and DOG-1,respectively.In the groups of moderate and high risk,positive expressions of CD117 and DOG-1 were 100.0%(40/40) and 97.5%(39/40),respectively.There was no relationship between the expression of CD117 and that of DOG-1.The expression of DOG-1 in GIST was not related to tumor initiation location,tumor size,clinical classification or patient age.DOG-1-negative expression was remarkably correlated with tumor recurrence and metastasis(P<0.01).Conclusion DOG-1 can be a potential reference marker for GIST diagnosis and prognosis.更多还原