【摘要】 目的探讨治疗前血红蛋白水平(HBC)对鼻咽癌患者(NPC)调强放疗(intensity-modulated radiation thera-py,IMRT)预后的影响。方法将250例鼻咽癌患者,根据放疗前血红蛋白水平分为3组(HBC<120 g/L组,HBC 120～150 g/L组,HBC≥150 g/L组)。结果 HBC<120 g/L、HBC 120～150 g/L、HBC≥150 g/L 3组3年局控率分别为92.9%、94.6%和93.2%,3年无远处转移生存率分别为92.9%、85.1%和90.0%,3年无瘤生存率分别为64.3%、76.4%和86.4%(P<0.01),3年总生存率分别为78.6%、83.8%和94.3%(P<0.01)。COX回归分析结果表明,治疗前血红蛋白水平是影响鼻咽癌患者预后的独立因素。结论 NPC患者放疗前HBC>150 mg/L,是影响患者无瘤生存率及总生存率的独立因素。更多还原

【Abstract】 Objective To explore the influence of preradiation peripheral blood hemoglobin concentration on the prognosis of patients with nasopharyngeal carcinoma(NPC)after radiotherapy.Methods Clinical and follow-up data of 250 NPC patients who received intensity-modulated radiation therapy were divided into three groups according to the peripheral blood hemoglobin concentration before radiotherapy(HBC<120 g/L,HBC 120～150 g/L and HBC≥150 g/L).Results The 3 year local control rates(L-FFR) were 92.9%,94.6% and 93.2%;the distant metastasis-free survival rates(FDM) were 92.9%,85.1% and 90.0%;the disease-free survival rates(DFS) were 64.3%,76.4% and 86.4% and the overall survival rates(OS) were 78.6%,83.8% and 94.3% in three groups respectively.By means of Cox regression analysis,the results demonstrated that the pre-radiation hemoglobin level was the independent factor on the prognosis of patients with nasopharyngeal carcinoma(NPC)after radiotherapy.Conclusion The HBC≥150 g/L is the independent factor that can affect DFS and OS on the prognosis of patients with nasopharyngeal carcinoma(NPC).更多还原