【摘要】 目的:研究p53蛋白表达与上皮性卵巢癌恶性程度及预后的关系。方法:采用免疫组化SP法测定26例上皮性卵巢癌中p53蛋白表达。结果:p53蛋白在黏液性、浆液性、内膜样卵巢癌中的表达率(88.9%、75%、100%)无明显差异(P>0.05);三种卵巢癌的复发率分别为33.3%、12.5%、0,以黏液性癌最高,三者之间有显著差异(P<0.05);p53蛋白在淋巴结转移卵巢癌患者中均为高表达(100%),与无淋巴结转移者(68.75%)相比差异明显(P<0.05);另外,淋巴结转移卵巢癌患者的复发率(40%)较无淋巴结转移患者(6.25%)明显增高(P<0.05)。p53蛋白在I-II期和III-IV期卵巢癌的高表达(50%、100%)具有显著差异(P<0.01),不同期别卵巢癌复发的几率也存在显著差异,其中I-II期复发率为0,III-IV期复发率为31.25%。结论:p53蛋白的高表达与上皮性卵巢癌的恶性程度及预后有着密切的关系。更多还原

【Abstract】 Objective: To investigate the significance of p53 expression of epithelial ovarian carcinoma.Methods:To use immunohistoehemical method to detect the p53 expression in 26 patients with epithelial ovarian carcinoma.Results: The expression of p53 protein in epithelial ovarian cancer(pituita,serosity,intima) had no significant difference(88.9%,75%,100%)(P > 0.05) in these three groups,while the recurrence rates among three cancer subtypes were significantly different(33.3%,12.5%,0).p53 protein expression in patients with lymph node metastasis was very strong(100%),and there was significant difference between the former and that without lymph node metastasis(68.75%)(P < 0.05).The recurrence rate of the patients with lymph node metastasis(40%) was higher than that without lymph node metastasis(6.25%),(P < 0.05).The high expression of p53 protein in ovarian cancer between I-II(50%) stage and III-IV stage(100%) was significantly different(P < 0.05),and the recurrence rate was different(P < 0.05).Conclusion: The expression of p53 protein has relationship with malignancy degree and prognosis of ovarian cancer.更多还原