【摘要】 目的:观察慢性心力衰竭(CHF)患者血浆β-内啡肽(β-EP)及神经肽Y(NPY)的变化,并探讨其与心功能的相关性。方法:选取84例CHF患者和120例健康人,收集各研究对象的一般资料,并采集晨起空腹外周血,用放射免疫法测定血浆β-EP和NPY水平,采用ATL-5000型彩色多普勒超声诊断仪检测左心室射血分数(LVEF)、心输出量(CO)。结果:不同性别和年龄组间CHF患者的血浆β-EP和NPY水平差异无统计学意义(P>0.05),不同病因所致CHF患者的血浆β-EP和NPY水平差异也无统计学意义(P>0.05)。CHF组与对照组血浆β-EP和NPY水平差异有统计学意义。血浆β-EP和NPY水平随着CHF患者NYHA心功能分级升高而升高。β-EP与NPY呈正相关,β-EP和NPY水平与LVEF及CO呈负相关。结论:CHF患者血浆β-EP和NPY水平随心功能变化而改变,可作为评估CHF程度的一种参考指标。更多还原

【Abstract】 Objective: To investigate the relation among plasma levels of β-endorphin(β-EP),neuropeptide Y(NPY) and cardiac function in patients with chronic heart failure(CHF).Methods: General informations of having been selected 84 cases of CHF patients and 120 healthy controls were collected on the study and collection of their peripheral blood early morning on an empty stomach,the β-EP and NPY concentration of 84 patients with CHF and 120 healthy controls were measured divided by radioimmunoassay.The left ventricular ejection fraction(LVEF)and cardiac output(CO)was measured with ALT-5000 echocardiography.Results: The plasma levels of β-EP,NPY had no significant differences by gender and age(P>0.05) in CHF patients,as well as in various causes of CHF(P>0.05).But plasma β-EP,NPY levels had significant differences between CHF and control group.The plasma levels of β-EP,NPY were significantly higher than those healty controls according to NYHA functional classification.The plasma levels of β-EP was positively correlated with plasma NPY level,and LVEF or CO was negatively corelated with plasma β-EP,NPY level.Conclusions :The plasma levels of β-EP and NPY with CHF patients changed with cardiac functional classification,can be used as a reference to evaluate the severity of CHF.更多还原