【摘要】 实验在研究聚焦超声结合二氢卟吩e6抑制小鼠肝癌H-22移植瘤增殖的基础上,通过酶化学方法检测不同处理后小鼠肝癌H-22移植瘤组织内超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶活性的变化,利用硫代巴比妥酸法检测丙二醛活力变化.结果显示,超声结合二氢卟吩e6能有效抑制H-22肿瘤组织的生长,同时其处理后肿瘤组织内MDA的含量显著升高,超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶活性均有不同程度的下降,提示超声激活二氢卟吩e6诱导的氧化损伤可能在抑制肿瘤组织生长过程中起主要作用.更多还原

【Abstract】 The synergistically killing effect of Chlorine e6 combining with ultrasound on Ehrlich ascites tumor bearing mice was determined.Enzymatic chemical method was used to measure the lipid peroxidation levels and activities of key antioxidant enzymes(ie,superoxide dismutase,glutathione peroxidase,catalase activities and MDA level) in Ehrlich ascites tumor after treatment.The results indicated that Chlorine e6 combining with ultrasound could inhibit the growth of Ehrlich ascites tumor tissue.Superoxide dismutase,glutathione peroxidase and catalase activities decreased and MDA level increased significantly in the treated tumor tissue.The changes in antioxidant enzyme activities and MDA level suggest that oxidative damage may play an important role in the anti-tumor effect in Ehrlich ascites tumor bearing mice treated by Chlorine e6 combining with ultrasound.更多还原