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脐血干细胞向不同体细胞分化的研究进展

Research Progress of Umbilical Cord Blood Stem Cells Differentiated into Various Kinds of Somatic Cells

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【作者】 籍凤宇李佳佳陈秀莉马利兵

【Author】 Ji Fengyu1.2 Li Jiajia1 Chen Xiuli1.3 Ma Libing1(1School of Mathematics,Physics and Biological Engineering,Inner Mongolia University of Science and Technology,Baotou 014010; 2The First Affiliated Hospital of Baotou Medical College,Baotou 014010;3Faculty of Biological Science and Technical, Baotou Teachers College,Baotou 014030)

【机构】 内蒙古科技大学数理与生物工程学院包头医学院第一附属医院包头师范学院生物科学与技术学院

【摘要】 脐血干细胞是一种具有多分化潜能的原始细胞,具备自我更新和增殖的能力,并能在特定因素的影响或诱导下,向多种细胞或组织分化。脐血来源的间充质干细胞不但可以分化为骨、脂肪和软骨,还可以转变成带有神经、肝脏及骨骼肌特异标记的细胞,并且具有应用到组织损伤修复、基因治疗载体和造血干细胞共移植等方面的潜力。旨在对于脐血干细胞在一定条件下分化为多种细胞研究进展进行综述。

【Abstract】 Umbilical cord blood stem cells(UCBSCs) are a kind of primitive cells,which have the potential of multidifferentiation,self-renewal and proliferation.When induced by special factors,UCBSCs can differentiate into several kinds of cells and tissues.Mesenchymal stem cells derived from umbilical cord blood can differentiate into many types of cells,including bone cells,fat cells and cartilage cells.In addition,they can also change into cells with labels specific for nerve cells,liver cells and skeletal muscle cells.Mesenchymal stem cells can be applied in the fields of repairing damaged tissue,gene therapy vectors and hematopoietic stem cells transplantation.In this review,umbilical cord blood stem cells,in a certain condition,differentiated into various kinds of somatic cells were concluded.

【基金】 内蒙古自治区自然科学基金项目(2009BS0503);内蒙古高等学校科研项目(NJ09093);内蒙古科技大学创新基金项目(2009NC058)
  • 【文献出处】 生物技术通报 ,Biotechnology Bulletin , 编辑部邮箱 ,2012年01期
  • 【分类号】R329
  • 【被引频次】6
  • 【下载频次】605
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