【摘要】 羟基磷灰石掺锶具有优化材料生物学及理化性能的作用,而由掺锶导致材料组织学反应的机理有待开展进一步的研究。将微波等离子方法制备的4种不同锶含量的掺锶羟基磷灰石(Sr-HA)陶瓷植入实验狗肌肉中,观察其肌肉内组织学反应,样品中掺锶量分别为0、1、5、7mol%。植入周期分别为4、8和12周。在12周时,组织学观察结果显示,在掺锶5mol%以下时,刺激反应轻度,而且掺锶5mol%的植入样品周围有较多的骨组织存在,掺锶量7mol%的羟基磷灰石陶瓷对肌组织有害,减少了诱导成骨的量。锶含量为5%时,组织反应轻度而且诱导生成的新骨组织生长良好,可考虑应用于临床。更多还原

【Abstract】 Strontium added into porous hydroxyaptite ceramics has the functions of improving its osseointegration,decreasing its dissolution rate and improving the bone density.Strontium-containing hydroxyaptite(Sr-HA) ceramics has been used as bone replacement and scaffold to treat the osteoporosis and bone default in clinic,but the mechanism of interfacial tissue response caused by the trace element Sr in Sr-HA ceramics still remains to be further studied.Four types of Sr-HA ceramic samples with different contents of Sr were prepared by microwave plasma sintering for testing the response of the soft tissue implanted in dog muscles in our laboratory.The contents of Sr element in the samples are 0mol%,1mol%,5mol%,and 7mol%,respectively.The samples were implanted in the muscle of the dogs for 4 weeks,8 weeks and 12 weeks,respectively.The histological observations at the end of each period showed that the irritant ranking increased with the content of Sr in Sr-HA ceramics at the end of 12 weeks,and there were rich bone tissue in Sr-HA ceramic samples with 5mol% Sr element.The overdose of element Sr is harmful to soft tissues.When the content of Sr in Sr-HA ceramic was below 5mol%,the soft tissue response was very slight and the new bones were induced to grow well.更多还原