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疏血通对慢性肺心病急性加重患者红细胞膜黏弹特性的影响

The Influence Shuxuetong on the Membrane Viscoelasticity of Erythrocyte Taken from Patients with Chronic Pulmonary Heart Disease

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【作者】 张燕梅同华吴泽志

【Author】 Zhang Yan1,2 Mei Tonghua3 Wu Zezhi41(Department of Respiratory,the Second Affiliated Hospital of Chongqing Medicine University,Chongqing 400010,China)2(Department of Respiratorye,Chongqing Zhongshan Hospital,Chongqing 400013,China)3(Department of Respiratory,the First Affiliated Hospital of Nanchan University,Nanchan 330006,China)4(College of Bioengineer,Key Lab for Biomechanics & Tissue Engineering Bunder the State Ministry or Education,Chongqing University,Chongqing 400044,China)

【机构】 重庆医科大学附属第二医院呼吸内科重庆市中山医院呼吸内科南昌大学第一附属医院呼吸内科重庆大学生物工程研究院生物力学与组织工程教育部重点实验室

【摘要】 探讨疏血通对慢性肺心病急性加重期患者红细胞膜黏弹特性的影响。采用微管吸吮技术,定量测定了慢性肺源性心脏病患者体外使用疏血通前后红细胞膜的黏弹特性的变化情况。结果表明:一定浓度疏血通可降低红细胞膜的弹性模量、黏性系数。这为临床上在肺心病的综合治疗中包括改善红细胞变形性的药物或措施提供了实验依据。

【Abstract】 The present paper was aimed to explore the effect of Shuxuetong on the membrane viscoelasticity of erythrocyte taken from the acute phase patients suffering from chronic pulmonary heart disease.The membrane viscoelasticity of erythrocyte was taken from the acute phase patients suffering from chronic pulmonary heart disease.The changes of membrane viscoelasticity of erythrocyte after treated with shuxuetong were detected by micropipette aspiration technique.The results showed that the Shuxuetong of certain concentration could cause the decrease of membrane elastic modulus and viscous coefficients in acute phase patients suffering from chronic pulmonary heart disease.The study offers experimental evidences that the comprehensive treatment of pulmonary heart disease should involve the drug or measure to improve the erythrocyte deformability.

  • 【文献出处】 生物医学工程学杂志 ,Journal of Biomedical Engineering , 编辑部邮箱 ,2012年01期
  • 【分类号】R541.5
  • 【被引频次】6
  • 【下载频次】68
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