【摘要】 目的:探讨血清甘油三酯(TG)与急性缺血性脑卒中(AIS)早期预测之间的相关性。方法:我们收集了736例AIS患者。依据TG水平将患者分为5组。参照美国国立卫生研究院(为什么不参照我国的标准)卒中量表(NIHSS),将早期神经功能恶化(END)设定为≥4分,将新发症状开始一周后的早期临床改善(ECI)定为降低4分或以上。将各组内的END、ECI患者及两者都不是的患者进行比较。结果:高TG和低TG组患者发生END的风险显著高于正常组。高TG、低TG组以及临界组患者发生ECI的百分率显著低于正常组。多元回归分析显示高TG、低TG组以及临界组患者在END中的or值显著高于正常低值组(50-100 mg/dl)。AIS患者的甘油三酯(TG)水平与预后不良呈非线性的J型相关,与良好预后呈反J形相关。结论:在AIS的早期高TG和低TG都是预后不良的危险因素。更多还原

【Abstract】 Objective: To investigate the association between serum Triglyceride(TG) levels and early prognosis of AIS.Methods: We enrolled 736 consecutive patients with AIS.According to the TG level,patients were divided into 5 groups.With the guidelines of the National Institute of Health Stroke Scale(NIHSS),we defined early neurological deterioration(END) as a 4-point or greater deterioration of the NIH stroke scale score and early clinical improvement(ECI) as a 4-point reduction of NIHSS within a week after symptom onset.We compared patients with END,ECI,and neither END nor ECI.Results: The risk of END was significantly higher in the hyperTG and hypoTG groups than in the normal group.The percentages of ECI were significantly lower in the hypoTG,borderline,and hyperTG groups than in the normal group.For END,the multivariable adjusted odds ratios were significantly higher in the hypoTG,borderline,and hyperTG groups than in the low normal group(50 to 100 mg/dl).TG had a nonlinear,J-shaped association with poor outcome and a reverse J-shaped association with good outcome in AIS.Conclusion: Both hyperTG and hypoTG can be risk factors for poor early outcome in AIS.更多还原