【摘要】 目的:研究梓醇对鱼藤酮所致小鼠脑线粒体损伤的保护作用。方法:小鼠随机分为对照组、模型组和治疗组。模型组腹腔注射鱼藤酮21d;治疗组先注射鱼藤酮21 d,后用梓醇治疗10 d。测定小鼠中脑、纹状体和皮层中线粒体复合酶Ⅰ、谷胱甘肽(GSH)、乳酸脱氢酶(LDH)活性、膜电位、活性氧(ROS)的含量。结果:梓醇能够提高小鼠复合酶Ⅰ活性,增加GSH的含量,减少膜电位的丢失和活性氧的生成,抑制LDH的释放。结论:梓醇对鱼藤酮损伤小鼠脑线粒体具有保护作用。更多还原

【Abstract】 Objective: To study the effect of catalpol on the mitochondrial function of mice brain mitochondrial on rotenone-induced damage in mice.Methods: Mice were randomly divided into three group,control group,model group and therapy group.Model group was injected intraperitoneally(i.p.) with rotenone(1.5 mg/kg) for 21 days,therapy group was injected with rotenone for 21 days,then given catalpol(10 mg/kg) for 10 days.The activities of complex I and lactic dehydrogenase(LDH),mitochondrial membrane potential,content of reduced glutathione(GSH) and reactive oxygen species(ROS) in midbrain,striatum and cortex mitochondria of mice were assayed.Results: Catalpol could increase the activities of complex I,increase GSH contents,decrease the loss of mitochondrial membrane potential and restrain the release of LDH.Conclusion: Catalpol has protective effect on mice brain mitochondrial injury induced by rotenone.更多还原