【摘要】 目的:研究秋茄枝乙醇提取物(EEK)对链脲佐菌素(STZ)诱导的2型糖尿病(T2DM)大鼠肝脏和胰腺组织病理结构的影响。方法:以高脂饲料喂养联合STZ建立T2DM大鼠模型。大鼠分为为正常对照组、T2DM模型组、二甲双胍组、EEK低、中、高剂量组。大鼠给药4周后处死,取肝脏和胰腺进行组织病理学检查。结果:随着EEK剂量的增加,大鼠肝脏和胰岛组织的病理损伤逐步减轻。结论:EEK有助于修复STZ诱导的T2DM大鼠受损的肝脏和胰岛组织。更多还原

【Abstract】 Objective: To investigate the effect of ethanol extract from kandelia candel trunk(EEK) on pathological structure of liver and pancreas in type 2 diabetes mellitus(T2DM) rats induced by streptozotocin.Methods: The T2DM rat model was induced with high-fat diet and STZ.Rats were devided into normal control group,model group,metformin group,EEK low-dose group,EEK medium-dose group and EEK high-dose group.After 4W administration,the rats were sacrificed to perform histopathological examination.Results: The pathological damages of liver and pancreas were gradually reduced with increasing dosages of EEK in Rats Conclusion: EEK contributes to repairing damaged liver and pancreas in T2DM rats induced by STZ.更多还原