【摘要】 Munc13是C.elegans Unc-13和Drosophila Dunc-13在哺乳动物中的同系物,有四种亚型,是SNARE蛋白的调节蛋白之一。Munc13蛋白含有两个结构域:C1和C2结构域,DAG/佛波醇结合到C1结构域上,能增强Munc13-1促进囊泡成熟的能力。在神经递质的胞吐过程中,有许许多多的蛋白参与,其中Munc,Synaptotagmin和Rab等蛋白家族是其重要的调节因子。同时,囊泡的转运和分泌也需要这些功能特殊的蛋白质的参与。全面了解Munc13的结构域与功能及其在分泌中的地位和分泌模式,有助于其在临床医学中的应用,如其在胰岛素释放等分泌调节中起着的重要作用。更多还原

【Abstract】 Munc13 proteins constitute a family of 4 mammalian homologue of C.elegans Unc-13 and drosophila Dunc-13,which is one of the regulation proteins of SNARE protein.Munc13 proteins contain C1 domain and C2 domain.The binding of DAG/phorbol-ester to C1 domain leads to enhanced priming activity of Munc13-1.Many proteins participated in the process of synaptic transmission such as Munc,Synaptotagmin and Rab.Meanwhile,these critical proteins are involved in the process of vesicle translocation and secretion.It will help to know the application in clinical medicine to understand comprehensively the domains and the functions of Munc13,such as it plays a critical role in insulin release.更多还原