【摘要】 目的:探讨IL-1、IL-6、TNF-α在COPD缓解期气道炎症中的作用及运动训练对COPD患者血清细胞因子的影响,为COPD患者制定最佳运动模式提供依据。方法:对55例临床缓解期的COPD患者进行为期12周运动训练,运动训练前后采用双抗体夹心ABC-ELISA法检测患者血清中细胞因子值,并与60名健康老年人比较。结果:COPD缓解期患者运动训练前,血清中IL-1、IL-6、TNF-α值均显著高于正常老年人组(P<0.01);经运动训练后,IL-1、TNF-α值显著下降(P<0.01),且不同运动训练方法,血清细胞因子变化幅度不同,以太极拳训练组IL-1、TNF-α下降的幅度最大(P<0.01)。结论:IL-1、IL-6、TNF-α参与了COPD缓解期气道慢性炎症反应,运动训练对致炎因子有下调作用,且太极拳运动训练下调效果较为明显。更多还原

【Abstract】 Objective: To investigate the role of IL-1,IL-6,and TNF-α on the airway inflammation in COPD remission stage and the influence of movement training on those serum cytokines,and to provide bases for development of the best movement pattem.Methods: 55 cases of clinical remission in patients with COPD experienced 12 weeks of movement training,before and after the training,using double-antibody sandwich ABC-ELISA assay determined serum IL-1,IL-6,and TNF-α levels,and meanwhile controlled with 60 healthy elderly people.Results: Before training,the serum IL-1,IL-6,TNF-α values in patients with COPD were significantly higher than the normal elderly group(P<0.01);but after training,IL-1 and TNF-α values decreased significantly(P<0.01).And diverse movement training pattem showed a different influence on the serum cytokines levels.In Taijiquan training group the IL-1 and TNF-α levels decreased significantly(P<0.01).Conclusion: IL-1,IL-6 and TNF-α involve the chronic airway inflammation reaction in COPD remission stage and movement training,specially the Taijiquan training,can reduce throse proinflammatory cytokines levels.更多还原