【摘要】 目的:研究黑龙江地区汉族人2型糖尿病家系的PON2基因9 Ser311C→G多态性,探讨其与2型糖尿病发病的关系。方法:应用聚合酶链式反应-限制性内切酶长度多态性(PCR-RFLP)技术,对来自于黑龙江地区120个2型糖尿病家系中的210例2型糖尿病患者及319例正常对照的PON2基因9 Ser311→Cys(C→G)位点进行基因分型。结果:PON2基因9 Ser311C→G三种基因型在病例组和对照组间整体分布没有统计学意义(P=0.610,df=2);各基因型及等位基因在病例组和对照组间分布没有统计学意义(P>0.05)。结论:PON2基因9 Ser311C→G多态性与黑龙江地区汉族人2型糖尿病无关,PON2基因可能不是中国人2型糖尿病发病的相关易感基因。更多还原

【Abstract】 Objective: To detect PON2 gene 9 Ser311C→G polymorphism in Heilongjiang Han families with type 2 diabetes and to investigate their relationship with type 2 diabetes.Methods: PCR-RFLP method was used to detect the site of PON2 gene 9 Ser311→Cys(C→G) in 210 individuals from 120 type 2 diabetes families and 319 normal control subjects in Heilongjiang area.Results: The overall distribution of the three genotypes of PON2 gene 9 Ser311C→G between cases and controls had no significant difference(P=0.610,df=2).The distribution of the all of the genotypes and alleles between cases and controls had no significant difference(P>0.05).Conclu-sion: PON2 gene 9 Ser311C→G polymorphism is not related to type 2 diabetes in Heilongjiang Han nationality.PON2 gene may not be a related gene of type 2 diabetes in Chinese.更多还原