【摘要】 抑癌基因磷酸酶与张力蛋白同源物(phosphatase and tensin homolog,PTEN)基因的功能缺失往往会形成多种类型的癌症,它的表达在转录和转录后水平都受到严格的调控。本文对PTEN表达的调控机制以及PTEN的相关核质转运机制进行了综述。更多还原

【Abstract】 Loss of function of PTEN,a tumor suppressor gene,usually contributes to the development of many cancers.It appears to be regulated both in transcriptionally and post-transcriptionally.Here we discuss recent progress in the mechanisms of PTEN regulation and entering the nucleus.更多还原