【摘要】 RanBPM是Ran蛋白在微管组织中心的结合蛋白。RanBPM包含5个结构域,分别是氨基端的脯氨酸结构域、SPRY结构域、LiSH结构域、CTLH结构域和CRA结构域。其中SPRY结构域和CRA结构域介导RanBPM与其它蛋白质间相互作用。RanBPM能与众多蛋白质相互作用,因而被认为是脚手架蛋白(scaffolding protein),它和几种受体蛋白相互作用后参与了细胞内多种信号转导途径。RanBPM能与细胞周期相关蛋白相互作用,调节细胞周期,它还参与了免疫系统、生殖系统和神经系统的调节。此外,RanBPM还能抑制蛋白质泛素化,是一个肿瘤细胞的抑制因子。更多还原

【Abstract】 RanBPM is aRan-bindingprotein in the microtubule-organizing center.RanBPM consists of five domains, including proline-rich SH3-binding motifs,SPRY,LiSH,CTLH and CRA domains.SPRY and CRA domain play an important role in mediating protein-protein interactions.RanBPM is known as the scaffolding protein because it can be associated with a lot of proteins.RanBPM interacts with receptors and participates in multiple signal pathways.RanBPM is associated with cell cycle-related proteins and regulates the progression of cell cycle.And RanBPM is involved in the regulation of immune system,reproductive system and nervous system.In addition,RanBPM can inhibit protein ubiquitination and acts as a tumor suppressor.更多还原