【摘要】 目的观察健脾消脂汤治疗2型糖尿病合并非酒精性脂肪肝的临床疗效。方法采用随机、对照的方法,将60例2型糖尿病合并非酒精性脂肪肝患者分为治疗组和对照组各30例。在基础治疗的基础上,治疗组予以健脾消脂汤治疗,对照组采用护肝片治疗,3个月后观察两组患者肝功能、空腹及餐后血糖、血脂、空腹血清胰岛素、胰岛素抵抗指数、胰岛分泌功能指数、B超等以评价疗效。结果健脾消脂汤治疗组总有效率显著高于对照组(P<0.01)。治疗组的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、甘油三酯(TG)、血清总胆固醇(T-CH)、极低密度脂蛋白(VLDL)较治疗前明显下降(P<0.05或P<0.01),与对照组比较,差异有统计学意义(P<0.05或P<0.01)。治疗组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、胰岛素抵抗指数(HOMA-IR)的降低及胰岛分泌功能指数(HBCI)的升高,与治疗前比较,差异有统计学意义(P<0.01),且优于对照组(P<0.05或P<0.01)。各组治疗前后空腹血清胰岛素(FINS)无明显变化。治疗组肝脏影像学方面的恢复程度均优于对照组。结论健脾消脂汤对2型糖尿病合并非酒精性脂肪肝有较好的治疗作用,值得进一步研究、应用。更多还原

【Abstract】 Objective To observe the clinical efficacy of jianpi xiaozhi decoction in the treatment of type 2 diabetes mellitus combined with non-alcoholic fatty liver.Methods The randomized controlled method was adopted to divide 60 cases of type 2 diabetes mellitus combined with non-alcoholic fatty liver into a treatment group and a control group,30 cases in each one.On the basis of the foundational therapy,jianpi xiaozhi decoction was supplemented in the treatment group,and hugan tablets were supplemented in the control group.In 3 months,the liver function,fasting blood glucose(FBG),post-prandial blood glucose(PPBG),blood lipid,fasting serum insulin(FINS),the insulin resistance index(HOMA-IR),insulin secretion indicator,ultrasonic B test and the others were observed for the efficacy assessment.Results The total effective rate in the treatment group with jianpi xiaozhi decoction was higher significantly than that in the control group(P<0.01).In the treatment group,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma glutamyl transpeptidase(GGT),triglyceride(TG),serum total cholesterol(T-CH)and very low density lipoprotein(VLDL)were all reduced remarkably as compared with those before treatment(P<0.05 or P<0.01),and the statistical significant differences presented as compared with the control group(P<0.05 or P<0.01).In the treatment group,the reducing of FPG,2hPG and HOMA-IR as well as the increasing of HBCI were different significantly in statistics as compared with those before treatment(P<0.01),and were superior to the control group(P<0.05 or P<0.01).There was no change in FINS before and after treatment in each group.The recovery degree in terms of liver imageology in the treatment group was better than that in the control group.Conclusion Jianpi xiaozhi decoction achieves the good efficacy on type 2 diabetes mellitus combined with non-alcoholic fatty liver and deserves to have a further study and application.更多还原