【摘要】 目的研究非酒精性脂肪肝(NAFLD)患者血清游离脂肪酸(FFA)水平及其与胰岛素抵抗(IR)的关系。方法测定118例NAFLD患者(NAFLD组)及103名健康体检者(正常对照组)的血清FFA并计算胰岛素抵抗指数(HOMA-IR)。结果 NAFLD组血清FFA浓度为(752.50±101.42)μmol/L,HOMA-IR为1.48±0.42,均高于正常对照组[(441.75±95.64)μmol/L,0.67±0.33](P<0.01)。NAFLD组FFA与HOMA-IR呈正相关(r=0.325,P<0.05)。结论 FFA与NAFLD密切相关,FFA致NAFLD可能通过IR起作用。更多还原

【Abstract】 Objective To investigate the relationship between serum free fatty acid(FFA) and insulin resistance(IR) in patients with non-alcoholic fatty liver disease(NAFLD).Methods A total of 118 patients with NAFLD and 103 healthy subjects were enrolled as NAFLD group and control group.Their serum FFA were measured,and homeostasis model assessment-insulin resistance(HOMA-IR) indices were calculated.Results The level of serum FFA was(752.50±101.42) μmol/L,and HOMA-IR was 1.48±0.42 in NAFLD group.The levels of serum FFA and HOMA-IR were higher than those in control group [(441.75±95.64) μmol/L,0.67±0.33](P<0.01).Serum FFA level was positively correlated with HOMA-IR in NAFLD group(r=0.325,P<0.05).Conclusions FFA is closely associated with NAFLD,and IR may play a role in the pathogenesis of FFA to NAFLD.更多还原