【摘要】 神经纤维缠结是阿尔茨海默病(Alzheimer’s disease,AD)的重要病理特征之一,其发生发展因素一直是相关研究领域的热点问题.神经纤维缠结由异常磷酸化的Tau蛋白错误折叠、聚集所形成,因此对诱发Tau蛋白异常磷酸化的因素进行探究显得尤为重要.Tau蛋白异常磷酸化逐渐形成神经缠结是AD早期发生的病理过程之一,本文就Tau蛋白异常磷酸化发生的环境影响因素进行了讨论.更多还原

【Abstract】 Neurofibrillary tangles(NFTs) are regarded as one of the major pathological features of Alzheimer’s disease,and are composed of misfolded and aggreagted Tau protein with hyperphosphorylation.But the mechanism of Tau hyperphosphorylation still remains to be clarified.This review summarized the roles of endogenous and exogenous factors in the induction of Tau hyperphosphorylation.The level of some factors and the hyperphosphorylation of Tau could be used as biomarkers for the early processing of AD.更多还原